allylestrenol

Allylestrenol is a synthetic progestogen (progestin) structurally related to progesterone, used primarily to prevent premature labor and recurrent or threatened miscarriage in pregnant women. It acts as an agonist of the progesterone receptor, supporting pregnancy by promoting endometrial receptivity for embryo implantation, maintaining the uterine lining, and relaxing uterine smooth muscle. Its mechanism of action is multimodal: it stimulates trophoblastic function (enhancing production of human chorionic gonadotropin and thus endogenous progesterone), exerts placentotropic effects, and has β2-adrenergic activity that relaxes myometrial muscle to inhibit uterine contractions. Allylestrenol is metabolized in the liver (mainly via CYP3A4), with a biological half-life of several hours; its main active metabolite is 17α-allyl-19-nortestosterone[1][2][3][6][8]. The drug has little estrogenic or androgenic activity compared to other 19-nortestosterone derivatives.

Brand names

GestinAstanolProlin ALutaninNidanolPregdotFetugardNidagestProfarRensureArandalAroserineCobarenolElmolanGravynonMaintane TabPerselinPregnolinTurinal

Other names

allylestrenol