Drug intelligence / Profile preview

aloe barbadensis mill. extract

Development stage
Unknown
Lead developer
Calmino group
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Aloe barbadensis Mill. extract (specifically the standardized extract AVH200) is a botanical extract derived from the inner leaf gel of the *Aloe barbadensis* Miller (Aloe vera) plant. Developed by Calmino Group, it is formulated as a certified medical device (marketed under the brand name ProIBS) for the treatment of symptoms associated with irritable bowel syndrome (IBS), including abdominal pain, bloating, diarrhea, and constipation. The extract contains gel-forming polysaccharides (such as acemannan) that support and protect the intestinal mucosal barrier. Additionally, it has been shown to possess immunomodulatory properties, including the reduction of T-cell activation and proliferation, and the suppression of pro-inflammatory cytokine secretion (such as IL-2, IFN-γ, and IL-17A) in vitro.

Brand names
PROIBS
Other names
aloe barbadensis Miller extractaloe barbadensis extractaloe vera extractaloe vera gel extractinner leaf gel extract of Aloe barbadensis Mill.
02

Targets

IFNG (Interferon gamma)IL-17A (Interleukin-17A)IL-2 (Interleukin 2)

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