aloe-derived extracellular vesicles

Aloe-derived extracellular vesicles (Aloe EVs) are plant-derived nanoscale membranous vesicles, typically 50-250 nm in diameter, isolated from various Aloe species including *Aloe vera*, *Aloe saponaria*, and *Aloe arborescens*. These vesicles function as biologic therapeutics or drug delivery vehicles, encapsulating a diverse cargo of bioactive compounds such as anthraquinones, polysaccharides, phenolic compounds, lipids, and proteins. Aloe EVs are being investigated for their ability to promote chronic wound healing and reduce fibrotic scarring by inducing M2 macrophage polarization and inhibiting myofibroblast activity. In dermatology, they have shown potential in mitigating skin photoaging by activating the Nrf2/ARE antioxidant pathway. In oncology, research suggests they can induce pyroptosis in pancreatic carcinoma cells via the ROS-GSDMD/E signaling pathway. Furthermore, Aloe EVs have demonstrated the capacity to cross the blood-brain barrier, facilitating the delivery of repurposed drugs like itraconazole for glioblastoma treatment. A Phase 1 clinical trial has also explored their use in managing insulin resistance and chronic inflammation associated with polycystic ovary syndrome (PCOS).

Other names

aloe vera-derived extracellular vesiclesAloe EVsaloe vera-derived exosomesaloe-derived exosomesAloe vera-derived extracellular vesicle-like particles