aloe vera + vitamin E

**Aloe vera + vitamin E** is a topical combination of aloe vera leaf extract and vitamin E (primarily α-tocopherol) used for wound healing and skin protection. Aloe vera provides anti-inflammatory, antimicrobial, and collagen-stimulating effects through polysaccharides like acemannan, promoting fibroblast proliferation, re-epithelialization, and granulation tissue formation. Vitamin E acts as a potent lipid-soluble antioxidant, neutralizing free radicals, stabilizing cell membranes, reducing oxidative stress, and enhancing collagen synthesis. Their synergy accelerates wound closure (up to 75% by day 14 in rabbit models), improves histopathological outcomes (dense collagen deposition, reduced inflammation), and boosts biochemical markers like hydroxyproline, SOD, and CAT activity, outperforming individual treatments.[1]