aloperine

Aloperine is a **quinolizidine alkaloid** primarily extracted from the roots of the plant *Sophora alopecuroides*. It is a natural product with documented biological activities including anti-inflammatory, antiviral, antitumor (anticancer), and immunomodulatory effects. Mechanistically, aloperine has been shown to inhibit various targets and pathways, such as PI3K/Akt, NF-κB, and Bcl-2 family proteins, depending on the disease model (notably in inflammation and cancers). It is not approved as a pharmaceutical but is researched as a bioactive lead compound in drug discovery for multiple disease indications.

Other names

4,5-dihydro-10,15-dimethylpyrido[1,2-a]quinolizidin-6-iumaloperin