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ALOTHIP-TH
- Development stage
- Unknown
- Lead developer
- Wellmed Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ALOTHIP-TH is a fixed-dose combination tablet marketed by Wellmed Pharma for the management of pain, inflammation, and muscle spasms associated with musculoskeletal disorders. It contains three active ingredients: aceclofenac, paracetamol (acetaminophen), and thiocolchicoside. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis by inhibiting cyclooxygenase (COX) enzymes. Paracetamol serves as an analgesic and antipyretic agent, providing additional pain relief. Thiocolchicoside is a semi-synthetic muscle relaxant with anti-inflammatory properties that acts as a selective GABAA receptor antagonist and glycine receptor agonist, effectively reducing muscle hypertonia. This multi-modal formulation is typically indicated for conditions such as low back pain, osteoarthritis, and acute muscle strains.
- Brand names
- ALOTHIP-TH
- Other names
- Thiocolchicoside + Aceclofenac + Paracetamol
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)δ-GABAAR (Extrasynaptic GABA-A receptor delta-containing subtype)Glycine receptorPGHS-1 (Prostaglandin G/H Synthase 1)
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