alovudine

Alovudine is a synthetic nucleoside analog of thymidine, classified as a pyrimidine 2',3'-dideoxyribonucleoside. It acts as a nucleoside reverse transcriptase inhibitor (NRTI), inhibiting viral DNA polymerase and thereby blocking the replication of retroviruses such as HIV. Alovudine was developed primarily for antiviral therapy against HIV, especially in patients with resistance to other NRTIs. The drug reached Phase II clinical trials but its development was discontinued due to dose-dependent toxicity concerns[1][5][7]. Mechanistically, it incorporates into viral DNA during reverse transcription and causes chain termination due to the absence of a normal hydroxyl group at the 3' position[1][5].

Other names

3'-deoxy-3'-fluorothymidine3'-Fluoro-3'-deoxythymidineThymidine, 3'-deoxy-3'-fluoro-fluorothymidineFddTFddThD3'F-TdRalovudinum