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alpha-1 antitrypsin
- Development stage
- Preclinical
- Lead developer
- Evolve Biologics
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Evolve Biologics is developing a plasma-derived alpha-1 antitrypsin (AAT) protein replacement therapy for the treatment of emphysema in patients with alpha-1 antitrypsin deficiency (AATD). The therapy is produced using Evolve's proprietary PlasmaCap EBA (Expanded Bed Adsorption) technology, which allows for the efficient extraction of proteins from human plasma. As an augmentation therapy, it works by replacing the deficient AAT protein, which is a natural inhibitor of neutrophil elastase. By restoring AAT levels, the drug aims to protect lung tissue from proteolytic damage and slow the progression of emphysema. It is currently in the preclinical stage of development and is intended for intravenous administration.
- Other names
- alpha-1 proteinase inhibitoralpha1 proteinase inhibitoralpha 1 proteinase inhibitorAAT
02
Targets
PRTN3 (Proteinase 3)ELANE (Human Neutrophil Elastase)CTSG (Cathepsin G)
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