Drug intelligence / Profile preview

alpha-amylase

Development stage
Unknown
Lead developer
AbbVie
Modality
Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

**Alpha-amylase** is a digestive enzyme primarily produced by the pancreas and salivary glands that catalyzes the hydrolysis of alpha-1,4 glycosidic bonds in complex carbohydrates like starch, converting them into simpler sugars, such as maltose and glucose. In pharmaceutical and supplement formulations, alpha-amylase is used for enzyme replacement therapy in conditions of pancreatic enzyme deficiency or chronic digestive disorders. Its mechanism of action involves cleaving starch into sugars to facilitate absorption in the small intestine. Alpha-amylase is also an important biomarker for pancreatic and salivary gland function and is measured to aid in the diagnosis of diseases such as acute or chronic pancreatitis, infections, and some metabolic or renal conditions. Industrially, alpha-amylase is utilized for starch processing, brewing, baking, and cleaning products[1][3][5][7].

Other names
α-amylaseptyalin (for salivary isoform)pancreatic alpha-amylase

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