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alpha-beta T cells - CD19 HD allogeneic CAR T
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
CD19 HD Allo CAR T is an allogeneic CAR-T cell therapy being developed by Editas Medicine in collaboration with Bristol Myers Squibb. The therapy consists of allogeneic alpha-beta (αβ) T cells engineered using CRISPR-based gene editing technology to target CD19, a protein expressed on the surface of B cells. Designed as an off-the-shelf treatment, it aims to treat various autoimmune diseases by depleting pathogenic B cells. This program represents Editas Medicine's first in-house developed technology for clinical use in the allogeneic CAR-T setting, and its IND/CTA has been accepted for Phase 1 clinical trials.
- Other names
- alpha-beta T cells - CD19 HD allogeneic CAR TCD19 HD allogeneic CAR TCD-19 HD allogeneic CAR TCD 19 HD allogeneic CAR T
02
Targets
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