Drug intelligence / Profile preview

alpha-bisabolol

Development stage
Phase 1
Lead developer
Symrise
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

Alpha-bisabolol is a natural monocyclic sesquiterpene alcohol primarily found in German chamomile (Matricaria recutita), Myoporum crassifolium, and the Brazilian Candeia tree. It appears as a colorless viscous oil with a weak sweet floral aroma that has been likened to apples, sugar, and honey. This compound possesses multiple pharmacological properties including anti-inflammatory, anti-irritant, anti-microbial, antioxidant, and skin-soothing effects. It's widely used in cosmetics and personal care products for its skin healing properties, including reducing wrinkles, skin toughness, and repairing sun-damaged skin. Alpha-bisabolol also functions as a penetration enhancer, increasing the absorption of certain molecules when used in topical formulations.

Brand names
Kamillosan舒瑞宁
Other names
levomenolbisabolol(-)-alpha-bisabololα-bisabololα-(−)-bisabolol
02

Targets

tBID (Truncated BID)BACE1 (Beta-site APP-cleaving enzyme 1)PPARG (Peroxisome proliferator-activated receptor gamma)AcetylcholinesteraseButyrylcholinesterase

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