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alpha-BSM
- Development stage
- Unknown
- Lead developer
- Etex Group
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Local Application
01
Overview
alpha-BSM is a biomimetic, endothermically setting apatitic calcium phosphate bone substitute material. Developed by Etex Corporation, it is designed to be injectable and hardens at body temperature (37°C) to form a poorly crystalline hydroxyapatite, which closely resembles the mineral phase of natural bone. The material is osteoconductive, providing a scaffold for new bone growth, and is gradually resorbed and replaced by native bone through cell-mediated remodeling by osteoclasts and osteoblasts. Beyond its use as a structural filler for fractures and dental defects, alpha-BSM serves as a delivery vehicle for therapeutic agents such as recombinant human bone morphogenetic protein-2 (rhBMP-2) and antibiotics like gentamicin, enhancing its regenerative and therapeutic potential in orthopedic and dental applications.
- Brand names
- Alpha-BSM
- Other names
- apatitic calcium phosphateα-BSMalpha-BSM bone substitute
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