Drug intelligence / Profile preview

alpha-cyanoacrylate

Development stage
Unknown
Lead developer
Toagosei
Modality
Small Molecules
Administration
Topical
01

Overview

Alpha-cyanoacrylate is an organic compound and the parent structure of the cyanoacrylate family, which are strong, fast-acting adhesives widely used in industrial, medical, and household applications. In medicine, cyanoacrylates—including derivatives such as ethyl cyanoacrylate and 2-octyl cyanoacrylate—are used as tissue adhesives for wound closure and surgical procedures. These adhesives polymerize rapidly in the presence of moisture to form a strong bond with biological tissues. The mechanism of action involves rapid anionic polymerization upon contact with water or tissue fluids, resulting in a durable adhesive layer that can close wounds or bond medical devices[4][1][2]. Alpha-cyanoacrylates have been studied for their biocompatibility and are subject to regulatory standards for use in humans[5]. They offer advantages such as faster wound closure compared to sutures and reduced risk of needle-stick injuries but may cause local irritation or allergic reactions[2][5].

Other names
α-氰基丙烯酸alpha-cyanoacrylic acid
02

Targets

Surface-exposed primary amines on tissue proteins

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