alpha-enolase siRNA

ENOA siRNA knockdown refers to the experimental or therapeutic silencing of the alpha-enolase (ENOA) gene using small interfering RNA (siRNA). Alpha-enolase is a multifunctional 'moonlighting' protein that acts as both a key glycolytic enzyme and a cell-surface plasminogen receptor. In pancreatic ductal adenocarcinoma (PDAC), ENOA is frequently overexpressed and contributes to tumor progression, metabolic reprogramming, and invasiveness. Research, notably from the University of Turin, has demonstrated that silencing ENOA in PDAC cell lines (such as CFPAC-1) leads to reduced cell proliferation, decreased survival, and impaired colony formation. These effects are partially mediated by increased production of intracellular reactive oxygen species (ROS) and alterations in cell adhesion and metabolic pathways. Preclinical studies in mouse models have shown that ENOA knockdown significantly reduces the formation of lung tumor masses, suggesting its potential as a therapeutic target for pancreatic cancer management.

Other names

ENOA siRNAENO1 siRNAENO-1 siRNAENO 1 siRNAalpha-enolase knockdown