alpha-galactosidase

Alpha-galactosidase is an **enzyme** that hydrolyzes terminal, non-reducing α-D-galactose residues in oligosaccharides, polysaccharides, glycolipids, and glycoproteins, facilitating the digestion of complex carbohydrates and helping to prevent gas, bloating, and digestive discomfort caused by undigested carbohydrates. It is used as an **over-the-counter digestive enzyme supplement**, as well as in enzyme replacement therapy for Fabry disease (where recombinant forms are used). The enzyme is produced industrially from sources like *Aspergillus niger* for dietary supplements. The mechanism of action involves cleavage of α-1,6 and α-1,3 linked galactosides, thereby reducing fermentable carbohydrates that cause gas production in the intestine. In human genetics, deficiency leads to Fabry disease, but in dietary supplements the enzyme is aimed at aiding digestion and reducing flatulence.

Brand names

BeanoGas-X Prevention

Other names

alpha-d-galactosidaseα-galactosidasealpha-galactosidase Aalpha-D-galactoside galactohydrolaseα-GALα-GAL A