Drug intelligence / Profile preview

alpha-lipoic acid

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral, Intravenous, Topical
01

Overview

Alpha-lipoic acid is a naturally occurring fatty acid and antioxidant that plays a role in mitochondrial energy metabolism. It acts as a cofactor for mitochondrial enzyme complexes and helps regenerate other antioxidants such as vitamin C and glutathione. As an antioxidant supplement (nutraceutical), it has been studied for use in diabetic neuropathy (nerve pain), weight loss support in diabetes or obesity management programs; wound healing; lowering blood sugar; improving skin discoloration from vitiligo; reducing complications after coronary artery bypass graft surgery; and potentially slowing cognitive decline in dementia. However its efficacy for many of these uses remains unproven or only modestly supported by clinical evidence. It is not FDA-approved as a pharmaceutical drug but is widely available as an over-the-counter dietary supplement[2][4][5].

Brand names
Alpha-Lipoic-Acid-300Alpha-Lipoic-Acid300Alpha-Lipoic-Acid 300Alpha Lipoic AcidALAmax ProtectALAmax CRAlpha Lipoic Sustain
Other names
Acetate Replacing FactorA-Lipoic AcidAcide Alpha-LipoïqueAcide Alpha-Lipoïque RAcide DL-Alpha-LipoïqueAcide LipoïqueAcide ThioctiqueAcide 1,2-dithiolane-3-pentanoïqueAcide 1,2-dithiolane-3-valériqueAcido Alfa LipoicoR-ALAR-Alpha-Lipoic Acid(R)-Lipoic AcidR-S-Alpha Lipoic AcidLipoic AcidDihydrolipolic acidDHLABiletanLipocin
02

Targets

DLAT (Dihydrolipoamide S-acetyltransferase)LTA4H (Leukotriene A4 hydrolase)Kir (Inward-rectifier potassium channels)Complex II (Succinate dehydrogenase)

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