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alpha-lipoic acid + acetyl-L-carnitine + omega-3 fatty acids + coenzyme Q10 + multivitamin
- Development stage
- Unknown
- Lead developer
- Columbia University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
The nutraceutical combination developed at Columbia University refers to a specific regimen of dietary supplements used as part of the ENT (Exercise, Nutraceuticals, and dietary recommendations Therapy) protocol for Chronic Fatigue Syndrome (CFS). This combination was evaluated in clinical trials (such as NCT01471652) based on the hypothesis that CFS involves mitochondrial dysfunction in the brain and skeletal muscle. The stack consists of alpha-lipoic acid, acetyl-L-carnitine, omega-3 fatty acids (specifically maxDHA), and coenzyme Q10 (CoQ10), supplemented with a multivitamin. These agents are intended to support mitochondrial energy production, reduce oxidative stress, and improve metabolic efficiency, mirroring treatments used for primary mitochondrial disorders.
- Other names
- nutraceuticals-Columbia UniversityENT nutraceuticalsENT therapy nutraceutical stack
02
Targets
PPAR (PPAR family)CPT1 (Carnitine palmitoyltransferase family)PDH (Pyruvate dehydrogenase complex)ND1 (Mitochondrial electron transport chain complex I)
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