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alpha-lipoic acid-loaded folate-conjugated chitosan nanoparticles

Development stage: Preclinical
Lead developer: Mashhad University of Medical Sciences
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules

Overview

**Alpha-lipoic acid-loaded folate-conjugated chitosan nanoparticles** are an investigational nanoparticle drug-delivery formulation developed for neuroprotection in Parkinson's disease models. The formulation encapsulates the antioxidant small molecule alpha-lipoic acid in chitosan nanoparticles surface-conjugated with folic acid, intended to enhance cellular delivery through folate-receptor-associated uptake. In an in vitro 6-hydroxydopamine-induced SH-SY5Y Parkinson's disease model, the formulation reduced oxidative stress, inflammatory signaling, and apoptosis, with greater protective activity than free alpha-lipoic acid. It is an early research formulation with no identified clinical trials, commercial manufacturer, approved indication, brand name, or sponsor development code.

Other names: FA-CS-ALA NPsfolic acid-chitosan-alpha lipoic acid nanoparticlesfolic acid-conjugated chitosan nanoparticles encapsulating alpha-lipoic acid

Targets

FOLR1 (FRα)

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