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Drug intelligence / Profile preview
alpha-methylserotonin
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
alpha-methylserotonin (also known as alpha-methyl-5-hydroxytryptamine) is a synthetic small molecule and a non-selective serotonin (5-HT) receptor agonist. It exhibits high affinity and agonist activity at multiple 5-HT receptor subtypes, particularly the 5-HT2 family (including 5-HT2A, 5-HT2B, and 5-HT2C) and several 5-HT1 subtypes (such as 5-HT1A, 5-HT1B, and 5-HT1D). Unlike endogenous serotonin, alpha-methylserotonin is resistant to metabolism by monoamine oxidase (MAO) due to the presence of the alpha-methyl group. It is widely utilized as a pharmacological research tool to investigate the physiological roles of the serotonergic system, including its effects on smooth muscle contraction, insulin secretion, and glycogen synthesis.
- Other names
- 5-hydroxy-alpha-methyltryptamine5-hydroxy-α-methyltryptaminealpha-Me-5-HTalpha-Me5-HTalpha-Me 5-HTalpha-methyl-5-HTalpha-methyl5-HTalpha-methyl 5-HTalpha-methyl-5-hydroxytryptaminealpha-methyl5-hydroxytryptaminealpha-methyl 5-hydroxytryptaminealpha-methylserotoninα-Me-5-HTα-methyl-5-HTα-methyl-5-hydroxytryptamineα-methylserotonin
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR1B (5-Hydroxytryptamine Receptor 1B)HTR1D (5-hydroxytryptamine receptor 1D)HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)
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