Drug intelligence / Profile preview

alpha-methylthiofentanyl

Development stage
Unknown
Modality
Small Molecules
Administration
Intravenous, Inhalation, Intranasal, Oral
01

Overview

alpha-methylthiofentanyl is a synthetic opioid analgesic and a structural analogue of fentanyl. Like other fentanyl analogues, it acts as an agonist at the mu-opioid receptor, producing potent analgesic effects as well as typical opioid side effects such as itching, nausea, and potentially life-threatening respiratory depression. It was briefly sold on the illicit market in the early 1980s before being controlled under drug laws due to its high abuse potential and risk profile. There is no accepted medical use for this compound in the United States or most other countries[1][2][3]. Its mechanism of action involves binding to mu-opioid receptors in the central nervous system, leading to inhibition of pain pathways and altered neurotransmitter release[6].

Other names
103963-66-2
02

Targets

MOR (Mu opioid receptor)

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