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alpha-tocopherol + beta-carotene + selenium

Development stage
Discontinued
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing three antioxidant micronutrients: alpha-tocopherol (a form of vitamin E), beta-carotene (a precursor to vitamin A), and selenium (an essential trace element). These compounds are known for their antioxidant properties, helping to neutralize free radicals and reduce oxidative stress in the body. Alpha-tocopherol acts as a lipid-soluble antioxidant protecting cell membranes, beta-carotene serves as an antioxidant and can be converted into retinol (vitamin A) in the body, while selenium is a cofactor for various selenoproteins involved in redox regulation and thyroid hormone metabolism. This combination has been studied primarily for its potential role in cancer prevention, cardiovascular health, immune support, and general nutritional supplementation. However, large clinical trials have not demonstrated clear benefits for cancer or chronic disease prevention; some studies have even shown increased risks with high-dose supplementation in certain populations such as smokers[2][3][4][5][6].

02

Targets

Polyunsaturated fatty acid lipid radicals (Lipid radicals)TTPA (Alpha-tocopherol transfer protein)

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