alpha-tocopheryloxyacetic acid lysine salt

Alpha-tocopheryloxyacetic acid lysine salt (α-TEA-LS) is an orally bioavailable, clinical-grade small molecule and the lysine salt form of alpha-tocopheryloxyacetic acid (α-TEA), a semi-synthetic, non-hydrolysable ether derivative of alpha-tocopherol (vitamin E). α-TEA-LS acts as a mitochondria-targeting agent that selectively induces tumor cell death by generating toxic reactive oxygen species (ROS), which triggers both apoptotic and autophagic pathways. In addition to its direct cytotoxic effects, the drug promotes immunogenic cell death (ICD) by stimulating the release of 'danger signals' such as heat shock proteins, ATP, and HMGB-1. This process facilitates dendritic cell cross-presentation and the priming of antigen-specific T cells, thereby enhancing the anti-tumor immune response. α-TEA-LS has been evaluated in Phase I clinical trials for patients with advanced solid tumors and has shown preclinical efficacy in breast cancer models, particularly when combined with immune checkpoint inhibitors.

Other names

alpha-tocopheryloxyacetic acid lysine saltalpha-TEA lysine saltα-TEA-LS