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alpibectir + ethionamide + rifampicin + ethambutol + pyrazinamide
- Development stage
- Unknown
- Lead developer
- BioVersys
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination therapy for tuberculosis that includes alpibectir, a novel small molecule that significantly potentiates the activity of ethionamide by acting on transcriptional regulators of Mycobacterium tuberculosis (Mtb), along with standard first-line TB drugs (rifampicin, ethambutol, and pyrazinamide). Alpibectir stimulates novel bioactivation pathways for ethionamide, increasing its efficacy while simultaneously overcoming ethionamide resistance. The combination is being developed for pulmonary and meningeal tuberculosis.
02
Targets
rpoB (DNA-directed RNA polymerase subunit beta)EthR;EthR2 (EthR/EthR2)VirS (VirS sensor histidine kinase)InhAMultiple pyrazinamide-associated bacterial targets/processesAftA (Arabinosyltransferase AftA)
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