alpinumisoflavone

Alpinumisoflavone is a **prenylated isoflavonoid** natural product isolated mainly from the unripe fruits of *Maclura tricuspidata* and also found in *Maclura pomifera* and *Ficus nervosa*. It exhibits a broad spectrum of preclinical pharmacological activities, including **anti-inflammatory**, **antioxidant**, **antimetastatic**, **antimicrobial**, **anticancer**, **antiangiogenic**, **estrogenic/antiestrogenic**, **antiosteoporotic**, **antidiabetic**, and **neuroprotective** effects[4][7][1]. Mechanistic studies indicate that alpinumisoflavone inhibits the expression of vascular endothelial growth factor (VEGF), fibrotic markers (alpha-SMA, collagen I), and pro-angiogenic signaling proteins (MMP-9, VEGFR-2, RET, HER2, EGFR, FGFR4) in cell and animal models. It has demonstrated safety and tolerability in animal studies at oral doses up to 100 mg/kg/day, and theoretical drug-likeness for oral or topical administration is high according to several rule-based drugability filters (Lipinski, Veber, Ghose, Egan, Muegge)[6]. No clinical trial, approved pharmaceutical formulation, or developer company is presently documented in public records.

Other names

Alpinum Isoflavone5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-6-one34086-50-55-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one