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alstonia boonei crude alkaloid fraction
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
The **alstonia boonei crude alkaloid fraction** consists of the isolated alkaloid-rich extract from the stem bark of *Alstonia boonei*, a West African medicinal plant from the Apocynaceae family[2][5]. This fraction is prepared by selective extraction and subsequent purification of the alkaloid components, which are identified via LCMS/MS to include eleven distinct alkaloids[2]. It displays pharmacological activities, notably **antiobesity effects** primarily through **inhibition of pancreatic lipase** and **suppression of adipogenesis in preadipocytes**[2]. It also possesses **antioxidant activity** (although weaker than other fractions and ascorbic acid) attributed to the presence of alkaloids and related phytochemicals[1]. Minor antimicrobial and anti-inflammatory effects are attributed to similar plant fractions[4][3]. Usage of this extract is primarily for *in vitro* and experimental purposes; it is not approved as a pharmaceutical product for clinical use.
- Brand names
- alstonia boonei crude alkaloid fraction
- Other names
- crude alkaloid fraction of alstonia booneiCAF (occasionally used in technical literature)
02
Targets
AMY (Pancreatic alpha-amylase)PNLIP (Pancreatic triacylglycerol lipase)
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