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altersolanol B
- Development stage
- Preclinical
- Lead developer
- California University of Science and Medicine
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
Altersolanol B is a natural tetrahydroanthraquinone (THAQ) metabolite isolated from fungi, such as *Alternaria* species. It is being investigated as a potential therapeutic agent for estrogen receptor-positive (ER+) breast adenocarcinoma. Altersolanol B acts as a selective estrogen receptor degrader (SERD), binding directly to the ligand-binding domain of estrogen receptor alpha (ERα) and inducing its proteasome-dependent degradation. Additionally, it has been shown to modulate multiple oncogenic signaling pathways, including the downregulation of AKT and ERK1/2 signaling, leading to intrinsic apoptosis in breast cancer cells.
- Other names
- ABdactylarin
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)MAPK3 (Mitogen-activated protein kinase 1)ESR1 (ERα)
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