Drug intelligence / Profile preview

althaea officinalis extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Althaea officinalis extract, commonly known as *marshmallow root extract*, is a botanical extract derived from the root of the Althaea officinalis plant. It contains bioactive constituents such as water-soluble polysaccharides (including galacturorhamnans, arabinans, glucans, and arabinogalactans), flavonoids, caffeic acid, p-coumaric acid, isoquercitrin, coumarins, phytosterols, tannins, and various amino acids[3]. The extract demonstrates antitussive (cough-suppressant), anti-inflammatory, antioxidant, antimicrobial, and mucosal-protective effects in preclinical and clinical settings[1][2][3]. Its mechanism as an antitussive is primarily attributed to forming a protective bioadhesive layer over irritated mucosa, reducing irritation and promoting regeneration, as well as modulating inflammatory mediator release and oxidative stress response[2][3]. Additional antibacterial actions are associated with high flavonoid and triterpenoid content that disrupt cell membranes and inhibit microbial adhesion and enzymatic activity[1]. It is primarily indicated for symptomatic relief of dry, irritable cough and mucosal irritation[2][3].

Brand names
Phytohustil
Other names
marshmallow root extractalthaea extractalthaea officinalis L. extractalthaea root extract
02

Targets

HYAL1 (Hyaluronidase-1)IL-6 (Interleukin 6)

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