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altropane
- Development stage
- Phase 3
- Lead developer
- Alseres Pharmaceuticals
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Altropane is a phenyltropane derivative and small molecule radiopharmaceutical developed primarily as a molecular imaging agent for the dopamine transporter (DAT). It acts as a potent dopamine reuptake inhibitor and binds specifically to DAT on the surface of dopamine-producing neurons. When radiolabeled with iodine-123 ([123I]), it is used in single photon emission computed tomography (SPECT) imaging to visualize DAT density in the brain. This property makes it useful for distinguishing Parkinsonian syndromes from other movement disorders by detecting reduced DAT levels characteristic of Parkinson's disease. Altropane has also been investigated for diagnostic use in attention deficit hyperactivity disorder (ADHD) and dementia[1][2][3][5][7][8].
- Brand names
- Altropane
- Other names
- 123-I Altropane[123I]-E-IACFT Injection[123I]NAV5001Iodine-123-E-IACFT InjectionIodine123-E-IACFT InjectionIodine 123-E-IACFT Injection
02
Targets
DAT (Dopamine plasma membrane transport protein)
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