Drug intelligence / Profile preview

aluminum chloride

Development stage
Phase 1
Modality
Small Molecules
Administration
Topical
01

Overview

Aluminum chloride is an inorganic compound with the formula AlCl3. It is most commonly used in medicine as a topical antiperspirant and astringent for the treatment of hyperhidrosis (excessive sweating), particularly in axillary (underarm), palmar (hand), and plantar (foot) regions. Its mechanism of action involves obstructing distal sweat gland ducts by precipitating with mucopolysaccharides and damaging epithelial cells along the duct lumen to form a plug that blocks sweat output. Aluminum chloride also acts as an astringent by promoting hemostasis through protein precipitation on superficial mucosal layers. In pharmaceutical manufacturing it may be used as an excipient or catalyst[1][2][3][4][5].

Brand names
Certain DriDrysolHypercareXerac ACHemobanHemox ALumicainSuperdent HemalTopical Hemo-stat
Other names
aluminum chloride hexahydratealuminium chloridealuminium trichloride
02

Targets

MUC5AC (Mucin-5AC)

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