aluminum hydroxide + magnesium hydroxide + diphenhydramine

This drug is a compounded combination of three active ingredients: - **Aluminum hydroxide** and **magnesium hydroxide** are antacids that work by neutralizing gastric acid, providing symptomatic relief from heartburn, acid indigestion, and upset stomach. They act locally in the gastrointestinal tract to increase pH and reduce irritation caused by excess stomach acid[6][7][9][10]. - **Diphenhydramine** is an antihistamine with anticholinergic properties. In this context, it provides local anesthetic effects and helps relieve pain or discomfort associated with oral mucositis or mouth sores. This combination is most commonly used as part of "magic mouthwash," a compounded oral rinse prescribed to manage pain from oral mucositis (such as that caused by chemotherapy or radiation), aphthous ulcers, or other painful inflammatory conditions of the mouth[3][4][8]. The mechanism involves both neutralization of acids (aluminum/magnesium hydroxides) and local analgesia/antihistaminic effect (diphenhydramine).

Other names

magic mouthwash