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Aluminum subacetate is a small molecule astringent and antiseptic used topically to prevent infection and treat irritation, particularly around the rectum and for minor skin irritations. It acts by precipitating proteins on the surface of tissues, which helps to relieve itching, reduce inflammation, and provide a cooling and drying effect. Aluminum subacetate is also active against certain bacteria such as *Staphylococcus aureus* and *Pseudomonas aeruginosa* by damaging their cell walls. It is commonly found in over-the-counter preparations for temporary relief of conditions like insect bites, athlete's foot, poison ivy/oak/sumac rashes, eczema (off-label), diaper rash (off-label), acne (off-label), pruritus ani (off-label), swelling from minor bruises (off-label), and excessive foot sweating (off-label)[1][2][3][5].
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