Drug intelligence / Profile preview

ALW-II-49-7

Development stage
Unknown
Lead developer
Harvard Medical School
Modality
Small Molecules
01

Overview

ALW-II–49–7 is a small molecule inhibitor primarily known for its activity against the discoidin domain-containing receptor tyrosine kinase 2 (DDR2). DDR2 is a receptor tyrosine kinase implicated in cell adhesion, proliferation, and extracellular matrix remodeling. Inhibition of DDR2 by ALW-II–49–7 has been studied in the context of cancer biology, particularly for its potential to block tumor cell invasion and metastasis. The compound is used as a chemical probe in preclinical research to elucidate DDR2 signaling pathways and their role in disease processes. It is not approved for clinical use and remains an experimental tool compound[1][3][4].

Other names
5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide5-((2-Methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)pyridine-3-carboxamide1135219-23-6CHEMBL552425CHEMBL-552425CHEMBL 552425DB07970DB-07970DB 07970CHEBI:91325
02

Targets

DDR2 (Discoidin domain receptor tyrosine kinase 2)DDR1 (Discoidin domain receptor 1)

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