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AMA1-DiCo
- Development stage
- Phase 1
- Lead developer
- Inserm
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**AMA1-DiCo** is an investigational recombinant protein-subunit malaria vaccine designed to prevent *Plasmodium falciparum* malaria. It contains three diversity-covering recombinant variants of *P. falciparum* apical membrane antigen 1, a polymorphic parasite protein involved in host-cell invasion. The multivariant antigen design aims to induce broadly cross-reactive anti-AMA1 antibodies against genetically diverse parasite strains. AMA1-DiCo was evaluated in a completed randomized Phase 1a/1b study in malaria-naive European adults and malaria-exposed African adults, administered intramuscularly with either GLA-SE or Alhydrogel as an adjuvant.
- Other names
- AMA1-DiCoAMA-1-DiCoAMA 1-DiCoPfAMA1 DiCoPfAMA-1 DiCoPfAMA 1 DiCoPfAMA1-DiCoPfAMA-1-DiCoPfAMA 1-DiCo
02
Targets
AMA1 (Apical membrane antigen 1)
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