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ambrosia deltoidea pollen
- Development stage
- Unknown
- Lead developer
- ALK Abelló
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intradermal, Percutaneous, Inhalation, Intranasal
01
Overview
Ambrosia deltoidea pollen extract is a biological therapeutic and diagnostic agent derived from the pollen of the triangle-leaf bursage, a plant native to the Sonoran Desert. It is utilized in allergen immunotherapy (AIT) to treat allergic rhinitis, allergic conjunctivitis, and allergic asthma by inducing immunological tolerance. The extract is also used as a diagnostic tool in skin prick testing to identify patients with Type I hypersensitivity to this specific ragweed species. Its mechanism of action involves the modulation of the immune system, specifically by shifting the T-cell response from a Th2 to a Th1 profile, inducing regulatory T-cells (Tregs), and stimulating the production of allergen-specific IgG4 antibodies that block IgE-mediated mast cell degranulation.
- Brand names
- Greer Allergenic ExtractALK-Abelló Allergenic ExtractHollisterStier Allergenic Extract
- Other names
- Triangle-leaf Bursage Pollen ExtractTriangle-leaf Ragweed Pollen ExtractAmbrosia deltoidea pollen extract
02
Targets
FCER1 (Fc epsilon RI receptor)IgE (Immunoglobulin E)
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