Drug intelligence / Profile preview

ambroxol + loratadine

Development stage
Unknown
Lead developer
Laboratorios Juste
Modality
Small Molecules
Administration
Oral
01

Overview

Balsofort is a fixed-dose combination of the second-generation antihistamine loratadine and the mucolytic agent ambroxol. Loratadine acts as a selective inverse agonist of peripheral histamine H1 receptors, preventing allergic responses such as sneezing, rhinorrhea, and itching without causing significant sedation. Ambroxol is a secretolytic agent that thins and liquefies thick bronchial secretions by stimulating surfactant production and enhancing mucociliary clearance. Developed and marketed by Industria Farmaceutica del Caribe (INFACA), Balsofort is approved for the symptomatic relief of cough, cold, and bronchopulmonary disorders complicated by allergic symptoms and thick mucus hypersecretion.

Brand names
Balsofort
Other names
ambroxol + loratadineambroxol hydrochloride + loratadineloratadine + ambroxolloratadine + ambroxol hydrochloride
02

Targets

GBA1 (Glucosylceramidase)HRH1 (Histamine H1 Receptor)SCN10A (Sodium channel protein type X alpha subunit)

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