AMC011 SOSIP

AMC011 SOSIP is a recombinant, soluble, native-like HIV-1 envelope glycoprotein (Env) trimer immunogen derived from the consensus sequence of early env genes from an elite neutralizer in the Amsterdam Cohort Studies on HIV/AIDS. The "SOSIP" design refers to specific stabilizing mutations that lock the gp120 and gp41 subunits into a prefusion conformation and render the protein soluble by truncating it at residue 664. This construct mimics the structure of functional viral spikes and is used as an immunogen to induce broadly neutralizing antibodies (bNAbs) against HIV-1 in vaccine research. The mechanism of action involves presenting conserved epitopes on the Env trimer surface to elicit bNAbs targeting key regions such as the fusion peptide and gp120-gp41 interface. The glycan shield of this construct is dominated by oligomannose glycans due to high glycan density and stabilization effects[1][2][6]. Compared with full-length membrane-bound trimers, AMC011 SOSIP trimers are more stable and do not bind non-neutralizing antibodies due to their conformational rigidity[2][6][9]. They are being evaluated for their ability to induce autologous and heterologous neutralizing antibody responses in preclinical models[4].

Other names

AMC011 Env trimerAMC-011 Env trimerAMC 011 Env trimerHIV-1 clade B Env trimer (AMC011)soluble native-like HIV-1 envelope trimer (AMC011)