Drug intelligence / Profile preview

Amcinonide

Development stage
Approved
Lead developer
Pfizer
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Amcinonide is a highly potent synthetic topical corticosteroid used to treat inflammation, redness, itching, and swelling associated with various dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. It acts primarily as an agonist of the glucocorticoid receptor. The anti-inflammatory effects are thought to result from the induction of phospholipase A2 inhibitory proteins (lipocortins), which inhibit the release of arachidonic acid—a precursor for inflammatory mediators like prostaglandins and leukotrienes. Amcinonide is available by prescription in forms such as cream, ointment, and lotion (typically 0.1%). Its primary indication is for skin conditions responsive to corticosteroids[1][2][3][4][5].

Brand names
Cyclocort
Other names
amcinonideCL-34699CL34699CL 34699
02

Targets

GR (Glucocorticoid receptor)

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