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American ginseng extract
- Development stage
- Unknown
- Lead developer
- CV Technologies
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
American ginseng extract is a botanical drug derived from the roots of *Panax quinquefolius*, a medicinal plant indigenous to North America. Its primary bioactive constituents are ginsenosides, which are triterpenoid saponins categorized into protopanaxadiol (PPD) and protopanaxatriol (PPT) types. The extract is investigated for its diverse therapeutic potential, including the prevention of respiratory infections in immunocompromised patients, such as those with chronic lymphocytic leukemia (CLL), and the enhancement of cognitive performance and neuroprotection. Additionally, it has shown promise in preclinical models for the treatment of inflammatory bowel diseases like ulcerative colitis and the prevention of peptic ulcers. Its pharmacological effects are attributed to its ability to modulate immune responses, reduce oxidative stress, and provide gastrointestinal mucosal protection.
- Brand names
- Cereboost
- Other names
- Panax quinquefolius extractPanax quinquefolius L. extractAmerican ginseng
02
Targets
GABRR (GABA-A receptor subunit rho)ESR1 (ERα)ABCB1 (P-glycoprotein)ESR2 (ERβ)CaV (Voltage-gated calcium channel protein complex)Nicotinic Acetylcholine ReceptorNMDAR (Glutamate receptor ionotropic, NMDA)Kir (Inward-rectifier potassium channels)
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