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amezinium metilsulfate
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Amezinium metilsulfate is a sympathomimetic small molecule drug primarily used for the treatment of hypotensive states, including essential and orthostatic hypotension. It acts by stimulating alpha and beta-1 adrenergic receptors, inhibiting monoamine oxidase (MAO), and blocking neuronal uptake of noradrenaline and tyramine. These combined actions increase blood pressure by enhancing sympathetic tone and reducing norepinephrine breakdown or reuptake. The drug is administered orally, with typical side effects including palpitations, headache, nausea/vomiting, hot flashes, and hypertension[2][5][7][8].
- Brand names
- RegultonSupratonin
- Other names
- amezinium methylsulfateamezinium methyl sulfateamezinium metisulfate4-amino-6-methoxy-1-phenylpyridazinium methylsulfate
02
Targets
ADRA1A (α1A)MAOA (Monoamine oxidase A)ADRB1 (β1)
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