amfenac

Amfenac is a non-steroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic properties. It acts as a potent inhibitor of cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins involved in inflammation, pain, and fever[1][3][6]. Amfenac is the active metabolite of nepafenac, which is used primarily for ocular indications such as pain and inflammation following cataract surgery. Amfenac itself has been studied for use in various inflammatory conditions including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, headache, dental pain, post-operative pain, menstrual pain (dysmenorrhea), arthralgia (joint pain), muscle pain and fever[5]. Its mechanism involves both reversible inhibition and unique time-dependent irreversible binding to COX enzymes[6][7].

Brand names

Amfenac

Other names

amfenaco2-(2-amino-3-benzoylphenyl)acetic acidamfenacum