AMG 076

AMG 076 is a potent and selective small molecule antagonist of the melanin-concentrating hormone receptor 1 (MCHR1). It was developed as an orally bioavailable agent targeting MCHR1 to regulate food intake and energy expenditure. In preclinical studies in mice and non-human primates with diet-induced obesity or high-fat diets, AMG 076 reduced body weight gain by decreasing food intake and increasing energy expenditure. These effects were associated with improved metabolic phenotypes such as increased glucose tolerance and insulin sensitivity. The drug was initially developed by Amgen for the treatment of obesity[1][5][7][8].

Other names

1-(2-((4aR,11R,11aS)-11-methyl-9-trifluoromethyl-1,3,4,4a,5,6,11,11a-octahydropyrido(4,3-b)carbazol-2-yl)ethyl)cyclohexanecarboxylic acid benzenesulfonic acid