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AMG 167 is an investigational biologic developed by Amgen for the treatment of osteopenia (low bone mineral density) in healthy men and postmenopausal women. It functions as a sclerostin (SOST) inhibitor, targeting the SOST protein to promote bone formation and increase bone mineral density. The drug has been evaluated in Phase 1 clinical trials (NCT01101048 and NCT00902356) to assess its safety, tolerability, and pharmacokinetics following subcutaneous administration. By inhibiting sclerostin, AMG 167 aims to counteract the natural suppression of bone formation, potentially offering a therapeutic approach for individuals with reduced bone mass.
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