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AMG9810
- Development stage
- Discontinued
- Lead developer
- Amgen
- Modality
- Small Molecules
- Administration
- Topical, Oral, Intraplantar Injection
01
Overview
AMG9810 is a potent and selective small molecule antagonist of the **transient receptor potential vanilloid 1 (TRPV1)** receptor, also known as the vanilloid receptor 1. Developed by **Amgen**, it acts as a competitive inhibitor that blocks TRPV1 activation by various stimuli, including capsaicin, heat, protons, and endogenous ligands. While it has been extensively used as a pharmacological research tool to investigate the role of TRPV1 in **inflammatory and neuropathic pain**, it has not transitioned into clinical development for medical use. In preclinical studies, AMG9810 demonstrated significant antihyperalgesic and analgesic properties, effectively blocking all known modes of TRPV1 activation.
- Other names
- (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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