amiflamine

Amiflamine is a small molecule drug that acts as a selective and reversible inhibitor of monoamine oxidase A (MAO-A), with a preferential effect on serotonin (5-HT) catabolism. The active form is the (+)-enantiomer. Amiflamine also functions as a serotonin releasing agent and has some activity as an inhibitor of semicarbazide-sensitive amine oxidase (SSAO). It shows higher affinity for the serotonin transporter compared to norepinephrine and dopamine transporters, allowing it to selectively inhibit MAO-A in serotonergic neurons at low doses. At higher doses, this selectivity diminishes. Amiflamine is structurally related to phenethylamine and amphetamine classes[1][2][3].

Other names

amiflaminaamiflaminum(+)-amiflamine(±)-amiflamine