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amikacin + cefotaxime
- Development stage
- Unknown
- Lead developer
- Daiichi Sankyo
- Modality
- Small Molecules
- Administration
- Intravenous, Intramuscular
01
Overview
A combination antibiotic regimen consisting of amikacin (an aminoglycoside) and cefotaxime (a third-generation cephalosporin). This combination demonstrates synergistic activity against various bacterial pathogens, particularly Gram-negative bacteria including resistant strains. It is primarily used for treating serious infections, especially in neutropenic patients with hematologic malignancies. The synergistic effect enhances bactericidal activity against organisms like Escherichia coli, Klebsiella species, and Pseudomonas aeruginosa.
02
Targets
Bacterial RibosomePBP (Penicillin-binding protein family)
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