amino acids (University of Iowa)

In the context of peptide receptor radionuclide therapy (PRRT) at the University of Iowa, **amino acids** refers to a specific intravenous solution, typically containing 25g of L-lysine and 25g of L-arginine, administered for renal protection. This solution is co-administered with radiopharmaceuticals such as 90Y-DOTATOC (yttrium-90-DOTATOC) to reduce the radiation dose to the kidneys. The amino acids work by competitively inhibiting the renal tubular reabsorption of the radiolabeled peptide, which otherwise accumulates in the proximal tubules and can cause nephrotoxicity. This supportive intervention is a critical component of dosimetry-guided PRRT protocols for treating somatostatin receptor-positive tumors, including neuroendocrine tumors, meningiomas, neuroblastomas, and medulloblastomas.

Other names

lysine + arginineL-lysine and L-arginine solutionrenal protective amino acid infusionprophylactic amino acid infusion