Drug intelligence / Profile preview

Amino L40

Development stage
Preclinical
Lead developer
Ajinomoto
Modality
Small Molecules
Administration
Oral
01

Overview

Amino L40 is a proprietary, leucine-rich blend of nine essential amino acids (EAAs) developed by Ajinomoto. It contains 40% L-leucine and 60% of the remaining eight essential amino acids (L-lysine acetate, L-valine, L-isoleucine, L-threonine, L-phenylalanine, L-methionine, L-histidine, and L-tryptophan) in a scientifically optimized ratio. Amino L40 is designed to stimulate muscle protein synthesis (MPS) and prevent muscle loss (sarcopenia) and physical frailty, particularly in older adults, patients with advanced chronic liver disease, or individuals undergoing rehabilitation. It acts primarily by activating the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, which triggers translation initiation and muscle protein anabolism.

Brand names
Amino L40Leucine 40Leucine40Leucine-40
Other names
AminoL40AminoL-40AminoL 40LEAALEAAsleucine-enriched essential amino acids
02

Targets

SESN2 (Sestrin-2)

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