aminoethyl nitrate

Aminoethyl nitrate is a small molecule organic nitrate ester formed by the condensation of ethanolamine and nitric acid. It acts as a vasodilator by generating nitric oxide (NO) upon metabolism, leading to relaxation of vascular smooth muscle and subsequent reduction in blood pressure. This mechanism underlies its use in the treatment of angina pectoris and ischemic heart disease. Unlike many other organic nitrates, aminoethyl nitrate has been shown to induce potent vasorelaxation without causing mitochondrial oxidative stress or endothelial dysfunction, and does not exhibit cross-tolerance with nitroglycerin or acetylcholine. Its unique pharmacological profile makes it an investigational candidate for cardiovascular therapy[1][3][7].

Brand names

ItraminNitrolamine

Other names

2-aminoethyl nitrate2-azanylethyl nitrate2-aminoethanol nitratenitric acid 2-aminoethyl esternitrooxyethylaminemonoethanolamine nitrate esterAramin