aminoguanidine

Aminoguanidine is a small molecule and diamine derivative of guanidine, primarily investigated as an inhibitor of advanced glycation end-product (AGE) formation. It acts by trapping reactive carbonyl species such as methylglyoxal, glyoxal, and 3-deoxyglucosone, thereby preventing the formation of AGEs implicated in diabetic complications and age-related diseases. Aminoguanidine also inhibits diamine oxidase and nitric oxide synthase (NOS), including inducible NOS (iNOS), contributing to its pharmacological effects on vascular function. Originally developed under the name pimagedine for diabetic nephropathy by Synvista Therapeutics, clinical development was discontinued due to safety concerns and lack of efficacy. It has been studied for other indications such as chronic renal failure, congestive heart failure, Alzheimer's disease, atherosclerosis prevention, and anti-aging applications in dietary supplements[2][3][4][6][9].

Brand names

AminoPro

Other names

pimageldineaminoguanidine hydrochlorideaminoguanidine bicarbonateN-aminoguanidineGER-11GER11GER 11