aminooxyacetic acid

Aminooxyacetic acid is a small molecule inhibitor of pyridoxal phosphate-dependent enzymes, most notably 4‑aminobutyrate aminotransferase (GABA transaminase or GABA-T). By inhibiting this enzyme, it increases gamma‑aminobutyric acid (GABA) levels in tissues. It also inhibits aspartate aminotransferase and other PLP-dependent enzymes by forming oxime-type complexes with the cofactor. Aminooxyacetic acid has been studied as a nootropic agent and anticonvulsant, and was previously investigated for Huntington's disease and tinnitus due to its effects on GABA metabolism. However, clinical use is limited by frequent side effects such as drowsiness, ataxia, seizures, psychosis, nausea, and dizziness at higher doses[1][2][3][7].

Other names

(aminooxy)acetic acidaminoxyacetic acidaminooxy-acetic acidcarboxymethoxylaminecarboxymethoxyamine2-aminooxyacetic acidaminooxyacetateacetic acid, (aminooxy)-(carboxymethoxy)amine(o-carboxymethyl)hydroxylamine